Aspidopterys obcordata vine inulin fructan affects urolithiasis by modifying calcium oxalate crystallization
| 论文编号: | |||||||||
| 作者: | Sun P | ||||||||
| 刊物名称: | Carbohydrate Polymers | ||||||||
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| 论文题目英文: | Aspidopterys obcordata vine inulin fructan affects urolithiasis by modifying calcium oxalate crystallization | ||||||||
| 年: | Oct 2022 | ||||||||
| 卷: | 294 | ||||||||
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| 页: | 119777 | ||||||||
| 联系作者: | Xu YK | ||||||||
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| 影响因子: | 10.723 | ||||||||
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| 摘要: | Aspidopterys obcordata vine is a Chinese Dai ethnic herb used to treat urolithiasis. However, the material basis and underlying mechanisms remain undefined. In this study, a 2.3 kD inulin-like A. obcordata fructan (AOFOS) was isolated by size exclusion column chromatography and characterized by ultrahigh-performance liquid chromatography-ion trap-time of flight mass spectrometry (UPLC-IT-TOF-MS), nuclear magnetic resonance (NMR) spectroscopy, gas chromatography mass spectrometry (GC–MS) and high-performance gel permeation chromatography (HGPC). In addition, AOFOS showed unique anti-urolithiasis activity in Drosophila kidney stone models. Mechanism study indicated that AOFOS reduced the size of calcium oxalate crystals by inhibiting the formation of large size crystals and the generation rate of calcium oxalate crystals as well as the crystal form conversion from calcium oxalate monohydrate (COM) to calcium oxalate dihydrate (COD). | ||||||||
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