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New bioactive peptides from the venom gland of a social hornet Vespa velutina 

 
论文编号:
作者: Meng YC
刊物名称: Toxicon
所属学科:
论文题目英文: New bioactive peptides from the venom gland of a social hornet Vespa velutina
年: Jun 2021
卷: 199
期:
页: 94-100
联系作者: Yang XW; Tan K
收录类别:
影响因子: 3.033
参与作者:
备注:
摘要: Bacterial resistance to drugs is a global problem requiring the urgent development of new antibiotics. Antimicrobial peptides (AMPs) are excellent candidates for the design of novel antibiotics to combat microbial resistance. In this research, we identified four new peptides (U-VVTX-Vp1a, U-VVTX-Vp1b, U-VVTX-Vp2a, and U-VVTX-Vp2b, respectively) from the venom of Vespa velutina, and tested their antimicrobial, antioxidant, and hemolytic effects. All four peptides showed scavenging ability against DPPH, ABTS+, and OH free radicals. Of note, Vp1b strongly inhibited the growth of Staphylococcus aureus and Escherichia coli bacteria at concentrations of 60 and 120 μM. Due to their low hemolytic activity, all four peptides could be utilized in the development of new antioxidants and as candidates for the design of novel antimicrobial agents.
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