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Bamboo shoot fiber improves insulin sensitivity in high-fat diet-fed mice 

 
论文编号:
作者: Li XF
刊物名称: Journal of Functional Foods
所属学科:
论文题目英文: Bamboo shoot fiber improves insulin sensitivity in high-fat diet-fed mice
年: Oct 2018
卷: 49
期:
页: 510-517
联系作者: Zhang P
收录类别:
影响因子: 3.470
参与作者:
备注:
摘要: The aim of this study was to evaluate the role of bamboo shoot fiber (BSF) in regulating insulin sensitivity in mice. Two BSFs were obtained from D. hamiltonii and D. latiforus. C57BL/6 mice were fed a low-fat diet or a high-fat diet with 10% fiber as cellulose (HFC), or two BSFs (HFDH or HFDL) for 13?weeks. Compared with the HFC group, HFDH and HFDL groups exhibited considerably less body weight gain, lower levels of fasting glucose and insulin, and lower values of glucose areas under the curve during glucose and insulin tolerance tests. BSF groups also had lower glucoses stimulated insulin concentrations. In addition, more phosphorylation of Akt in insulin target tissues was associated with higher protein expression levels of PGC-1α and phosphorylated AMPK and p38 in BSF fed mice. These results indicated that BSF improved insulin sensitivity in high-fat diet-fed mice through enhancing insulin signaling and activating PGC-1α.
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