The DELLA-CONSTANS transcription factor cascade integrates gibberelic acid and photoperiod signaling to regulate flowering
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| 作者: | Wang HP | ||||||||
| 刊物名称: | Plant Physiology | ||||||||
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| 论文题目英文: | The DELLA-CONSTANS transcription factor cascade integrates gibberelic acid and photoperiod signaling to regulate flowering | ||||||||
| 年: | Jul 2016 | ||||||||
| 卷: | online | ||||||||
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| 联系作者: | Yu DQ; Hu YR | ||||||||
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| 影响因子: | 6.280 | ||||||||
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| 摘要: | Gibberellin (GA) and photoperiod pathways have recently been demonstrated to collaboratively modulate flowering under long-days (LDs). However, the molecular mechanisms underlying this collaboration remain largely unclear. In this study, we found that GA-induced expression of FLOWERING LOCUS T (FT)under LDs was dependent on CONSTANS (CO), a critical transcription factor positively involved in photoperiod signaling. Mechanistic investigation revealed that DELLA proteins, a group of crucial repressors in GA signaling, physically interacted with CO. The DELLA-CO interactions repressed the transcriptional function of CO protein. Genetic analysis demonstrated that CO acts downstream of DELLA proteins to regulate flowering. Disruption of CO rescued the earlier-flowering phenotype of the gai-t6 rga-t2 rgl1-1 rgl2-1 mutant (dellap), while a gain-of-function mutation in GA INSENSITIVE (GAI, a member of the DELLA gene) repressed the earlier-flowering phenotype of CO-overexpressing plants. In addition, the accumulation of DELLA proteins and mRNAs was rhythmic, and REPRESSOR OF GA1-3 (RGA) protein was noticeably decreased in the long-day afternoon, a time when CO protein is abundant. Collectively, these results demonstrate that the DELLA-CO cascade inhibits CO/FT-mediated flowering under LDs, which thus provide evidence to directly integrate GA and photoperiod signaling to synergistically modulate flowering under LDs. | ||||||||
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