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Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae) 

 
论文编号:
作者: Liu B
刊物名称: Natural Product Research
所属学科:
论文题目英文: Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae)
年: Mar 2015
卷: online
期:
页:
联系作者: Xu YK
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影响因子: 1.225
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摘要:

Twelve compounds were isolated from the roots of Aglaia odorata. Their structures were established on the basis of NMR and MS data as rocaglaol (1), rocaglamide (2), eichlerialactone (3), sapelins A (4), isofouquierone (5), eichlerianic acid (6), shoreic acid (7), agladupol E (8), 3-epimeliantriol (9), cleomiscosins B (10), 2b,3b-dihydroxy- 5a-pregnane-16-one (11) and b-D-glucopyranos-1-yl N-methylpyrrole-2-carboxylate (12). Among them, compounds 1 and 2 showed significant cytotoxicity against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480) with IC50 values of 0.007–0.095mM, while compounds 35 and 10 and 11 showed moderate to no cytotoxicity (IC50 0.43 to values .40 mM). Compound 6 showed only weak cytotoxicity (IC50 6.87 to .40 mM) and its epmier 7 was completely inactivite (IC50 . 40 mM) in the assay. However, potent synergistic effect was observed when the molar ratio of 6 to 7 is between 4:1 and 1:1. 

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