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The F-box protein MIO1/SLB1 regulates organ size and leaf movement in Medicago truncatula

First Author: Zhou SL; Yang TQ
Abstract: The size of leaf and seed organs, determined by the interplay of cell proliferation and expansion, is closely related to the final yield and quality of forage and crops. Yet the cellular and molecular mechanisms underlying organ size modulation remain poorly understood, especially in legumes. Here, MINI ORGAN1 (MIO1) was identified as a key regulator of organ size, which encodes an F-box protein (SLB1) was recently reported to control lateral branching in M. truncatula. We show that loss of function of MIO1/SLB1 severely reduced organ size. Conversely, plants with overexpression of MIO1/SLB1 plants had enlarged organs. Cellular analysis revealed that MIO1/SLB1 controlled organ size mainly by modulating primary cell proliferation during the early stages of leaf development. Biochemistry analysis revealed MIO1/SLB1 could form part of an SKP1/Cullin/F-box (SCF) E3 ubiquitin ligase complex, to target BIG SEEDS1 (BS1), a repressor of primary cell division for degradation. Interestingly, we found that MIO1/SLB1 also played a key role in pulvinus development and leaf movement by modulating cell proliferation of the pulvinus as leaves developed. Our study not only demonstrates a conserved role of MIO1/SLB1 for organ size control in legumes, but also sheds light on the novel function of MIO1/SLB1 in leaf movement.
Contact the author: Chen JH
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Impact Factor: 5.908
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PubYear: Jan 2021
Volume: online
Publication Name: Journal of Experimental Botany
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