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Faculty and Staff
Leader of Functional Foods Group
Academic title:
Postal Code:
Subject categories:
Nutrition and Immunology
Mailing Address:
3214, Lab of Tropical Plant Resource Science Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences Menglun, Mengla, Yunan, China 666303

Texas A&M University, College Station, TX    Ph.D., Nutrition   2005

Lund University, Lund, Sweden    Master of Science, Food Science and Biotechnology;  1998 

Renmin University of China, Beijing, P.R.China

Master of Science in Economics    1996 

Bachelor of Science in Economics  1993 


Research Experience:

Postdoc Research Associate, Dept. of Pediatrics, Division of Medical Genetics, Duke University Medical Center                         2008. 8– 2012.8

  Research Fellow, Department of Microbiology & Immunology, University of Oklahoma Health Sciences Center                       2006.9 – 2008.7

 Research Fellow, Department of Pathology (Comparative medicine), School of Medicine, Wake Forest University and Center of Botanical Lipids at Wake Forest University and Brigham and Women’s Hospital      2005.8 – 2006.8      

My major interest is how nutrients affect immune system and function. My research in the past twelve years has been focused on two areas: (1) how polyunsaturated fatty acids affect immune function and lipid metabolism; (2) mechanisms of immune tolerance breakdown in autoimmune diseases as well as in gene therapy. 

 Future research of the group will be mainly investigating health benefits of phytochemicals from tropical plants particularly their immuno-modulatory roles. We will also explore the use of phytochemicals for intervention in immune mechanism mediated diseases. Another area is to study health benefits of Sacha Inchi oil (mainly on lipid metabolism and anti-inflammatory role). 


 Selected Publications:  

1.      Deficiency in MyD88 signaling results in decreased antibody responses to adeno-associated virus vector containing a CMV enhancer/chicken β-actin cassette in murine Pompe disease. Ping Zhang, Xiaoyan Luo, Andrew Bird, Songtao Li & Koeberl DD. 2012. BioResearch Open Access. Vol1, No.3, 109-114.

2.      Immunodominant, liver-specific expression suppresses transgene-directed immune responses in murine Pompe disease. Zhang, P., Sun, B., Osada T., Rodriguiz R., Yang X., Luo X, Kemper, A.R., Clay, T.M., and Koeberl, D.D.  Hum Gene Ther 2012 Mar 29 (Epub ahead of print).

3.      The role of TSC1 in regulating innate immunity. Pan, H.J., O’Brien, T., Zhang, P., & Zhong, X.P. J. Immunol 2012 Mar (Epub ahead of print).

4.      Rescue administration of a helper-dependent adenovirus vector with a long-term efficacy in dogs with glycogen storage disease type 1a. Gene Ther. 2012. Apr; 19 (4) 443-52. Crane B, Luo X, Demaster A, Williams KD, Kozink DM, Zhang P, Brown TT, Pinto CR, Oka K, Sun F, Jackson MW, Chan L, Koeberl DD.

5.      Cutting edge: Cardiac myosin activates innate immune responses through TLRs. Zhang, P., Cox C.J., Alvarez, K.M., Cunningham, M.W. 2009. The Journal of Immunology. Jul 1; 183(1):27-31.

6.       Echium oil reduces plasma lipids and hepatic lipogenic gene expression in   apoB100-LDL receptor knockout mice. Zhang, P., Boudyguina, E., Wilson, M.D., Gebre, A.K. & Parks, J.S. 2008. J. Nutr. Biochem. 19(10): 655-663.

7.      Dietary fish oil inhibits antigen-specific murine Th1 cell development by suppression of clonal expansion. 2006. Zhang, P., Kim, W., Zhou, L., Wang, N., Ly, L.H., McMurray, D.N. & Chapkin, R.S. Journal of Nutrition. 136, 2391-2398.

8.      Dietary n-3 polyunsaturated fatty acids modulate Th1/Th2 balance in vitro towards Th2 pole by suppression of Th1 development. 2005. Zhang, P., Smith, R., Chapkin, R.S. & McMurray, D.N. Journal of Nutrition. 135:1745-1751.

            In revision for Nature Medicine: 

9.      Rishu Guo, Chi-Keung Wan, Ping Zhang, Shudan Shen, Thomas O'Brien, Carpenter,Chenhu Liu, Yingxian Li, Balachandra Gorentla, A. J. Harris, Wesley Burks, and Xiao-Ping Zhong (2012).  Synergistic control of regulatory T cell function and self-tolerance to the liver by diacylglycerol kinases alpha and zeta.

 Presentations and invited talks 

Oral presentation at the 13th gene therapy meeting, 2010, Washington DC.

 Invited talk at center for genetics, National Jewish Health, CO. Oct, 2009.

   Poster presentation at the annual department of pediatrics research retreat, Duke University Medical Center, Durham, NC, June, 2009.

 Invited talk at Dept. of Immunology, St Jude Children’s hospital, Memphis, TX. Feb, 2008.

 Poster presentation at the 94th AAI meeting 2007 Miami.

 Poster presentation at 7th annual conference on arteriosclerosis, thrombosis and vascular biology. 2006. Denver.

Invited talk at Wake Forest University School of Medicine, Winston-Salem, NC, June 2005.

Invited talk at Gladstone Institute, UCSF, San Francisco, May 2005.

Invited talk at Baylor College of Medicine Dept. of Immunology, Houston, Texas, Mar. 2005.

 Experimental Biology Conference 2005, San Diego; oral and poster presentation.

  Texas Agriculture Conference, Feb 2005, poster presentation.

 Experimental Biology Conference 2004, Washington, DC, Poster presentation.

Community service:

Affiliations: American Society for Nutrition. American Association of Immunologists. American Society of Gene and Cell Therapy.

Commitment to research the situation: